|Title:||Application Of Experimental Design To Tert.-Methylcyclohexylation Of P-Cresol|
For screening variables, Plackett-Burman design was applied to study the reaction of p-cresol with 2-methycyclohexanol in the presence of perchloric acid as catalyst. Temperature, molar ratio of p-cresol to 2-methycyclohexanol and amount of perchloric acid were found to be important. A 3 factor 2-level Yates pattern experimental design was used to develop a mathematical equation for the reaction. The critical response was the yield of 2-tert.-methylcyclohexyl-4-methylphenol. Main effects as well as two- and three-factor interaction effects were statistically significant. The adequacy of the suggested model was checked up. The highest yield obtained was 91.2%.